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Another common cause of sudden weight loss in men is cancer. One of the most common cancer symptoms is sudden and unexplained weight loss. In fact, one of the ways that cancer is diagnosed in patients is when they approach the doctor complaining of sudden weight loss. Although this may be because the person is not feeling well and so, there may be loss of appetite. But there are cases where despite a healthy appetite a person may be rapidly losing weight. This is especially seen in cases of cancer of the gastrointestinal system, because when a person eats, then the food may not be getting properly absorbed in the gut.

The amount of weight loss experienced by a person is highly dependent on the type of cancer. Around 60% of patients who suffer from lung cancer and around 80% of people who have stomach cancer lose a significant amount of weight before they are diagnosed with cancer. Also, people who have advanced stages of cancer usually suffer from cachexia. This is a condition where there is weight loss and muscle wasting. This makes the person feel very weak and it is also seen in other conditions like AIDS and severe kidney diseases.